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LC-MS

Dissolution Apparatus

Time of Flight Mass Spectrometer

Waters SYNAPT Q TOF HDMS

Waters SYNAPT HDMS uses Q-TOF technology to determine the composition of small molecules by accurate mass spectrometry. It is becoming a powerful qualitative tool and more useful for structural analysis of fragment ions generated by tandem mass spectrometry. With the improvement of accurate mass measurement accuracy, the reliability of small molecule confirmation and structural analysis is significantly improved. Waters UPLC and SYNAPT HDMS combine to optimize the combination of chromatographic speed, sensitivity and resolution. The unique ion mobility provides a third dimension of separation, like isomer separation, allowing separate for co-eluting. Orthogonal TOF and TDC technology provides high resolution , sensitivity and acquisition speed, making it an ideal mass spectrometer for UPLC separation.

Parameters

M/Z range: quadrupole: up to 8000 amu

TOF: 20-100000amu

Resolution: 17500FWHM

Sensitivity:

MS positive ion sensitivity: instrument adjustment resolution is10000FWHM, 10μl of Leucineenkephalin 50/50 acetonitrile/water added to 01.%formic acid solution, M/Z=556 peak ion count per second is greater than 2000

MS positive ion sensitivity: 100 FMOL/L [Glu]-Fib rinopetide B solution,derived from the parent ion is the strongest y-fragment peak of M/Z=785.8Da,the ion count per second is greater than 130

Sensitivity of the nanoliter system:

MS positive ion sensitivity: 50 pg/μl of Leucineenkephalin 50/50acetonitrile/water added to 01.% formic acid solution, M/Z=556 peak ion countper second greater than 1700

MS positive ion sensitivity: 100 FMOL/L [Glu]-Fib rinopetide B solution,derived from the parent ion is the strongest y-fragment peak of M/Z=785.8Da,the ion count per second is greater than 130

Data conversion speed: >4.0GHz

Configuration

1.Waters SYNAPT Q-TOF mass spectrometer host (ESI ion source)

2.Pre-stage vacuum pump for mass spectrometry

3.Supporting software and computer (MassLynx V4.1 system software)

4.UPS uninterrupted protection power supply (optional)

Application solutions

Time of Flight Mass Spectrometer

Waters SYNAPT Q TOF HDMS

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