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Triple Quadrupole LCMSMS

AB SCIEX API 4000 LCMSMS

Whether you are a beginner or an experienced expert, the AB SCIEX API 4000 system addresses the most demanding drug development challenges. 1. The superior sensitivity of the mass spectrometry system ensures minimum detection limits for ultra-trace substance analysis, such as pesticide and veterinary drug residues in food safety, environmental analysis, and forensic toxicology, trace analysis of clinical studies. 2. The API 4000 LC/MS/MS system provides excellent quantitative and qualitative results for the analysis of low levels of compounds in complex matrices, providing reliable data from drug discovery to clinical trials while also accelerating the introduction of new products to the market. Conversion. 3. With advanced ion source, reliable interface and patented LINAC collision cell, good ion channel can accelerate ion transmission efficiency and achieve high-throughput detection and analysis.
Parameters

Mass range: at least 6amu, the maximum mass is not less than 2980 amu

Resolution(full mass range): unit mass resolution (full scan)

MRM sensitivity:

electrospray ionization ESI: positive ion 1 pg, Reserpine direct injection, MRM analysis609/195, signal to noise ratio > 2500:1 (RMS)

Negative ion 1pg chloramphenicol direct injection, MRM analysis 312/152, signal to noiseratio S/N>1400:1

APCI:1pg Reserpine direct injection, MRM analysis measurement 609/195, signal tonoise ratio >500:1 (peak to peak ratio)

Detection limit of mass spectrometry: Clenbuter detection limit ≤0.01ppb; chloramphenicol detection limit 0.01ppb

Scanning speed: maximum >2300 amu/sec

Dynamic linear range of data acquisition: >4*106

Linear Accelerated High Pressure Collision Chamber Design: Pressure greater than 7mtor, improves ion transmission efficiency, improves sensitivity, eliminates memory effects and cross-contamination

Quantitative analysis reproducibility:

low concentration: chloramphenicol 0.1 ppb, injection volume 20 μl, N=5, CV <3%;

High concentration: chloramphenicol 2ppb, injection volume 20μl, N=5, CV<3%;

5ppb;50ppb glycerol and cholesterol were injected 5 times respectively RSD<1%

One injection, regardless of time window: 300 compound MRM quantification andlibrary search simultaneously complete no loss of sensitivity, with actualspectral support.


Configuration

1. API4000 mass spectrometer host (ESI and APCI ion source)

2. Pre-stage vacuum pump for mass spectrometry

3. Supporting software and computer (Analyst 1.6.3 system software)

4. Supporting nitrogen generator (optional)

5. UPS uninterrupted protection power supply (optional)




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